Search results for "cholesterol 7α-hydroxylase"

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Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.

2001

The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL1, and H…

medicine.medical_specialtyOffspringmedicine.medical_treatmentLipoproteinsLCATIntraperitoneal injectionQD415-436GrowthReductaseBiologyBiochemistryStreptozocinDiabetes Mellitus ExperimentalFetal MacrosomiaPhosphatidylcholine-Sterol O-Acyltransferasechemistry.chemical_compoundEndocrinologyHMG-CoA reductasePregnancyInternal medicineDiabetes mellitusmedicineAnimalsmacrosomiaRats Wistarmaternal diabetesCholesterol 7-alpha-Hydroxylasecholesterol 7α-hydroxylaseCholesterolCell Biologymedicine.diseaseStreptozotocinAcetyl-CoA C-AcyltransferaseHydroxymethylglutaryl-CoA reductaseACATRatsEndocrinologyCholesterolchemistryLiverHydroxymethylglutaryl-CoA-Reductases NADP-dependentHyperglycemiaPrenatal Exposure Delayed EffectsGestationPregnancy Animallipids (amino acids peptides and proteins)FemaleHydroxymethylglutaryl CoA Reductasesmedicine.drugJournal of lipid research
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